An obligatory intermediate in the folding pathway of cytochrome c552 from Hydrogenobacter thermophilus.

@article{TravagliniAllocatelli2005AnOI,
  title={An obligatory intermediate in the folding pathway of cytochrome c552 from Hydrogenobacter thermophilus.},
  author={Carlo Travaglini-Allocatelli and Stefano Gianni and Vikash Kumar Dubey and Alessandro Borgia and Adele Di Matteo and Daniele Bonivento and Francesca Cutruzzol{\`a} and Kara L Bren and Maurizio Brunori},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 27},
  pages={25729-34}
}
The folding mechanism of many proteins involves the population of partially organized structures en route to the native state. Identification and characterization of these intermediates is particularly difficult, as they are often only transiently populated and may play different mechanistic roles, being either on-pathway productive species or off-pathway kinetic traps. Following different spectroscopic probes, and employing state-of-the-art kinetic analysis, we present evidence that the… CONTINUE READING

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