An nmr conformational analysis of a synthetic peptide Cn2(1-15)NH2-S-S-acetyl-Cn2(52-66)NH2 from the New World Centruroides noxius 2 (Cn2) scorpion toxin: comparison of the structure with those of the Centruroides scorpion toxins.

@article{Yamamoto1999AnNC,
  title={An nmr conformational analysis of a synthetic peptide Cn2(1-15)NH2-S-S-acetyl-Cn2(52-66)NH2 from the New World Centruroides noxius 2 (Cn2) scorpion toxin: comparison of the structure with those of the Centruroides scorpion toxins.},
  author={H Yamamoto and Jan Sejbal and Eunice J. York and John M Stewart and Lourival Domingos Possani and George Kotovych},
  journal={Biopolymers},
  year={1999},
  volume={49 4},
  pages={
          277-86
        }
}
The solution structure of a synthetic peptide, Cn2(1-15)NH2-S-S-acetyl-Cn2(52-66)NH2 from toxin 2 (Cn2) of the New World scorpion Centruroides noxius was determined using nmr and molecular dynamics calculations. The peptide has no significant secondary structure such as an alpha-helix or a beta-sheet, yet it has a fixed conformation for the first chain. The backbone secondary structure involving residues 6-12 in this peptide shows an excellent overlap with the structures of natural neurotoxins… Expand
2 Citations
Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides.
TLDR
The sera obtained were able to recognize Cn2 and to neutralize Cn1 in vitro and the most efficient protection was induced by rabbit anti-SP1 serum. Expand
Antibody BCF2 against scorpion toxin cn2 from Centruroides noxius hoffmann: Primary structure and three‐dimensional model as free fv fragment and complexed with its antigen
The antibody BCF2 generated against the mammal‐specific toxin Cn2 of the scorpion Centruroides noxius Hoffmann neutralizes the effect of both the toxin and the venom. We cloned and sequenced theExpand

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