An n-of-1 Trial Service in Clinical Practice: Testing the Effectiveness of Stimulants for Attention-Deficit/Hyperactivity Disorder

@article{Nikles2006AnNT,
  title={An n-of-1 Trial Service in Clinical Practice: Testing the Effectiveness of Stimulants for Attention-Deficit/Hyperactivity Disorder},
  author={C. J. Nikles and G. Mitchell and C. Del Mar and A. Clavarino and N. McNairn},
  journal={Pediatrics},
  year={2006},
  volume={117},
  pages={2040 - 2046}
}
  • C. J. Nikles, G. Mitchell, +2 authors N. McNairn
  • Published 2006
  • Medicine
  • Pediatrics
  • OBJECTIVE. We sought to describe the clinical use of n-of-1 trials for attention-deficit/hyperactivity disorder in publicly and privately funded family and specialized pediatric practice in Australia. METHODS. We used a within-patient randomized, double-blind, crossover comparison of stimulant (dexamphetamine or methylphenidate) versus placebo or alternative stimulant using 3 pairs of treatment periods. Trials were conducted from a central location using mail and telephone communication, with… CONTINUE READING
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