An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation.

@article{FernandezZapico2003AnMI,
  title={An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation.},
  author={Martin E Fernandez-Zapico and Ann C. Mladek and Volker Ellenrieder and Emma Folch-Puy and Laurence Miller and Raul A Urrutia},
  journal={The EMBO journal},
  year={2003},
  volume={22 18},
  pages={4748-58}
}
KLF11 is a biochemical paradigm for a subset of proteins that repress transcription via a Mad1-like mSin3A interacting domain (SID). The biological role of these proteins and the significance of their biochemical activity, however, remain to be established. We report that KLF11 is downregulated in human cancers, inhibits cell growth in vitro and in vivo, and suppresses neoplastic transformation. Transgenic mice for KLF11 display a downregulation of genes encoding the oxidative stress scavengers… CONTINUE READING