An mRNA region of the canine distemper virus fusion protein gene lacking AUG codons can promote protein expression

@article{Cherpillod2004AnMR,
  title={An mRNA region of the canine distemper virus fusion protein gene lacking AUG codons can promote protein expression},
  author={Pascal Cherpillod and Ljerka Zipperle and Riccardo Wittek and Andreas Zurbriggen},
  journal={Archives of Virology},
  year={2004},
  volume={149},
  pages={1971-1983}
}
Canine distemper virus (CDV) produces a glycosylated type I fusion protein (F) with an internal hydrophobic signal sequence beginning around 115 residues downstream of the first AUG used for translation initiation. Cleavage of the signal sequence yields the F0 molecule, which is cleaved into the F1 and F2 subunits. Surprisingly, when all in-frame AUGs located in the first third of the F gene were mutated a protein of the same molecular size as the F0 molecule was still expressed from both the… CONTINUE READING

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1 Excerpt

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