An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria immitis.

@article{Yates2004AnIG,
  title={An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria immitis.},
  author={Darran M Yates and Adrian J Wolstenholme},
  journal={International journal for parasitology},
  year={2004},
  volume={34 9},
  pages={1075-81}
}
Dirofilaria immitis is a filarial nematode that infects dogs and causes cardiopulmonary disease. The most effective way of controlling the infection is by chemoprophylaxis, using members of the avermectin/milbemycin (A/M) class of anthelmintics, which includes ivermectin; these drugs act at invertebrate glutamate-gated chloride channels (GluCl). We have cloned two cDNAs encoding D. immitis GluCl subunits and demonstrated that at least one may be an important molecular target for the A/Ms in… CONTINUE READING