An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation.

@article{Fujii2005AnIT,
  title={An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation.},
  author={Isao Fujii and Naho Yoshida and Shigeki Shimomaki and Hideaki Oikawa and Yutaka Ebizuka},
  journal={Chemistry & biology},
  year={2005},
  volume={12 12},
  pages={
          1301-9
        }
}
A biosynthetic gene cluster containing five genes, alt1-5, was cloned from Alternaria solani, a causal fungus of early blight disease to tomato and potato. Homology searching indicated that the alt1, 2, and 3 genes code for cytochrome P450s and the alt4 gene for a FAD-dependent oxygenase/oxidase. The alt5 gene encodes a polyketide synthase (PKS), named PKSN, that was found to be an iterative type I complex reduced-type PKS with a C-methyltransferase domain. To identify the PKSN function, the… CONTINUE READING
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