An iterative sequential mixed-integer approach to automated prostate brachytherapy treatment plan optimization.

@article{DSouza2001AnIS,
  title={An iterative sequential mixed-integer approach to automated prostate brachytherapy treatment plan optimization.},
  author={Warren D. D'Souza and Robert R. Meyer and Bruce R. Thomadsen and Michael C. Ferris},
  journal={Physics in medicine and biology},
  year={2001},
  volume={46 2},
  pages={297-322}
}
Conventional treatment planning for interstitial prostate brachytherapy is generally a 'trial and error' process in which improved treatment plans are generated by iteratively changing, via expert judgement, the configuration of sources within the target volume in order to achieve a satisfactory dose distribution. We have utilized linear mixed-integer programming (MIP) and the branch-and-bound method, a deterministic search algorithm, to generate treatment plans. The rapidity of dose falloff… CONTINUE READING

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