An isoform of microtubule-associated protein 4 inhibits kinesin-driven microtubule gliding.

@article{Tokuraku2007AnIO,
  title={An isoform of microtubule-associated protein 4 inhibits kinesin-driven microtubule gliding.},
  author={Kiyotaka Tokuraku and Taro Q. P. Noguchi and Makiko Nishie and Kazuyuki Matsushima and Susumu Kotani},
  journal={Journal of biochemistry},
  year={2007},
  volume={141 4},
  pages={585-91}
}
Recently, we revealed that microtubule-associated protein (MAP) 4 isoforms, which differ in the number of repeat sequences, alter the microtubule surface properties, and we proposed a hypothesis stating that the change in the surface properties may regulate the movements of microtubule motors [Tokuraku et al. (2003) J Biol Chem 278: 29609-29618]. In this study, we examined whether MAP4 isoforms affect the kinesin motor activity. When the MAP4 isoforms were present in an in vitro gliding assay… CONTINUE READING

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