An iron-dependent and transferrin-mediated cellular uptake pathway for plutonium.

@article{Jensen2011AnIA,
  title={An iron-dependent and transferrin-mediated cellular uptake pathway for plutonium.},
  author={Mark P Jensen and Drew Gorman-Lewis and Baikuntha P Aryal and Tatjana Paunesku and Stefan Vogt and Paul G Rickert and Soenke Seifert and Barry Lai and Gayle E. Woloschak and L Soderholm},
  journal={Nature chemical biology},
  year={2011},
  volume={7 8},
  pages={560-5}
}
Plutonium is a toxic synthetic element with no natural biological function, but it is strongly retained by humans when ingested. Using small-angle X-ray scattering, receptor binding assays and synchrotron X-ray fluorescence microscopy, we find that rat adrenal gland (PC12) cells can acquire plutonium in vitro through the major iron acquisition pathway--receptor-mediated endocytosis of the iron transport protein serum transferrin; however, only one form of the plutonium-transferrin complex is… CONTINUE READING
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