An ionizing radiation-sensitive mutant of CHO cells: irs-20. I. Isolation and initial characterization.

@article{Stackhouse1993AnIR,
  title={An ionizing radiation-sensitive mutant of CHO cells: irs-20. I. Isolation and initial characterization.},
  author={M A Stackhouse and Joel S. Bedford},
  journal={Radiation research},
  year={1993},
  volume={136 2},
  pages={241-9}
}
We have isolated a stable mutant of CHO cells, designated irs-20, that is hypersensitive to ionizing radiation. The selection system was designed to select for mutants unable to proliferate at the low dose rate of 0.06 Gy per hour, a dose rate that has little influence on the effect of radiation on the cell cycle of wild-type cells during 1- to 2-week exposures. The irs-20 mutant cells irradiated continuously at 0.06 Gy/h showed a cell cycle redistribution, with an increasing G2 + M-phase… CONTINUE READING
7 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…