An ion channel essential for sensing chemical damage.

  title={An ion channel essential for sensing chemical damage.},
  author={Lindsey J. Macpherson and Bailong Xiao and Kelvin Y. Kwan and Matt J. Petrus and Adrienne E. Dubin and SunWook Hwang and Benjamin F Cravatt and David P. Corey and Ardem Patapoutian},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={27 42},
Tissue damage and its downstream consequences are experimentally assayed by formaldehyde application, which indiscriminately modifies proteins and is presumed to cause pain through broadly acting mechanisms. Here we show that formaldehyde activates the ion channel TRPA1 and that TRPA1-deficient mice exhibit dramatically reduced formaldehyde-induced pain responses. 4-Hydroxynonenal, a reactive chemical produced endogenously during oxidative stress, and other related aldehydes also activate TRPA1… CONTINUE READING
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