An investigation of the sex difference in the diuretic response to ethacrynic acid in mice.

@article{Cooling1977AnIO,
  title={An investigation of the sex difference in the diuretic response to ethacrynic acid in mice.},
  author={Margaret Cooling and Malcolm Freeman Sim},
  journal={British journal of pharmacology},
  year={1977},
  volume={60 4},
  pages={
          569-72
        }
}
1. Female mice of the Hough/Porton and Tuck/TO strains were found to be more sensitive than male mice to the diuretic effects of oral and intravenous doses of ethacrynic acid. 2. The sensitivity of Hough/Porton male mice to ethacrynic acid was increased after pretreatment with stilboestrol and the sensitivity of female Hough/Porton mice decreased after pretreatment with testosterone. 3. There were no significant sex differences in the diuretic response to frusemide, acetazolamide, aminophylline… CONTINUE READING
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