An investigation of the endogenous formation of apparent total N-nitroso compounds in conventional microflora and germ-free rats.

@article{Massey1988AnIO,
  title={An investigation of the endogenous formation of apparent total N-nitroso compounds in conventional microflora and germ-free rats.},
  author={RelatedLanguagesB. C. Massey and Performance Key and Anthony K. Mallett and Ian R. Rowland},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1988},
  volume={26 7},
  pages={595-600}
}
The endogenous formation of apparent total N-nitroso compounds (ATNC) has been investigated in germ-free (GF) and conventional (CV) microflora rats as a function of the drinking-water nitrate concentration. ATNC levels were below the 40 micrograms (N-NO)/kg detection limit in the blood, liver, kidney, spleen and small intestine of all CV and GF rats. For the CV rats ATNC were detected in concentrations of up to 370 micrograms (N-NO)/kg in the large intestine and up to 50 micrograms (N-NO)/kg in… CONTINUE READING