An investigation of herpes simplex virus type 1 latency in a novel mouse dorsal root ganglion model suggests a role for ICP34.5 in reactivation.

@article{Mattila2015AnIO,
  title={An investigation of herpes simplex virus type 1 latency in a novel mouse dorsal root ganglion model suggests a role for ICP34.5 in reactivation.},
  author={Riikka K Mattila and Kirsi Harila and Salla M. Kangas and Henrik Paavilainen and Anthony M. Heape and Ian Mohr and Veijo Hukkanen},
  journal={The Journal of general virology},
  year={2015},
  volume={96 8},
  pages={
          2304-13
        }
}
After a primary lytic infection at the epithelia, herpes simplex virus type 1 (HSV-1) enters the innervating sensory neurons and translocates to the nucleus, where it establishes a quiescent latent infection. Periodically, the virus can reactivate and the progeny viruses spread back to the epithelium. Here, we introduce an embryonic mouse dorsal root ganglion (DRG) culture system, which can be used to study the mechanisms that control the establishment, maintenance and reactivation from latency… 
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