• DOI:10.14293/s2199-1006.1.sor-.pp5bwn4.v1
• Corpus ID: 218869050

An investigation of ethanolic propolis extracts: Their potential inhibitor properties against ACE-II receptors for COVID-19 treatment

@inproceedings{Gler2020AnIO,
  title={An investigation of ethanolic propolis extracts: Their potential inhibitor properties against ACE-II receptors for COVID-19 treatment},
  author={Halil İbrahim G{\"u}ler and Gizem Tatar and Oktay Yıldız and Ali Osman Belduz and Sevgi Kolaylı and Halil Ibrahim Guler and Gizem Tatar and Oktay Yıldız and Ali Osman Belduz and Sevgi Kolaylı},
  year={2020}
}

• H. Güler, Gizem Tatar, +7 authors S. Kolaylı
• Published 2020
• Chemistry, Biology

The angiotensin-converting enzyme (ACE)-related carboxypeptidase, ACE-II, is a type I integral membrane protein of 805 amino acids that contains one HEXXH-E zinc binding consensus sequence. ACE-II has been implicated in the regulation of heart function and also as a functional receptor for the coronavirus that causes the severe acute respiratory syndrome (SARS). In this study, the potential of some flavonoids present in propolis to bind to ACE II receptors was calculated in silico. Binding constants of ten flavonoids, caffeic acid, caffeic acid phenethyl ester, chrysin, galangin, myricetin, rutin, hesperetin, pinocembrin, luteolin and quercetin were measured using the AutoDock 4.2 molecular docking program. And also, these binding constants were compared to reference ligand of MLN-4760. The results are shown that rutin has the best inhibition potentials among the studied molecules with high binding energy -8,97 kcal/mol and Ki 0,261 M, and it is followed by myricetin, caffeic acid phenethyl ester, hesperetin and pinocembrin. However, the reference molecule has binding energy of -7,28 kcal/mol and 4,65 M. In conclusion, the high potential of flavonoids in ethanolic propolis extracts to bind to ACE II receptors indicates that this natural bee product has high potential for Covid19 treatment, but this needs to be supported by experimental studies.