An investigation of ethanolic propolis extracts: Their potential inhibitor properties against ACE-II receptors for COVID-19 treatment

  title={An investigation of ethanolic propolis extracts: Their potential inhibitor properties against ACE-II receptors for COVID-19 treatment},
  author={Halil İbrahim G{\"u}ler and Gizem Tatar and Oktay Yıldız and Ali Osman Belduz and Sevgi Kolaylı and Halil Ibrahim Guler and Gizem Tatar and Oktay Yıldız and Ali Osman Belduz and Sevgi Kolaylı},
The angiotensin-converting enzyme (ACE)-related carboxypeptidase, ACE-II, is a type I integral membrane protein of 805 amino acids that contains one HEXXH-E zinc binding consensus sequence. ACE-II has been implicated in the regulation of heart function and also as a functional receptor for the coronavirus that causes the severe acute respiratory syndrome (SARS). In this study, the potential of some flavonoids present in propolis to bind to ACE II receptors was calculated in silico. Binding… 

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