An investigation of depotentiation of long-term potentiation in the CA1 region of the hippocampus

@article{Bashir1994AnIO,
  title={An investigation of depotentiation of long-term potentiation in the CA1 region of the hippocampus},
  author={Z I Bashir and Graham L Collingridge},
  journal={Experimental Brain Research},
  year={1994},
  volume={79},
  pages={437-443}
}
We have investigated long-term synaptic depression in the CA1 region of rat hippocampal slices. Prolonged low-frequency stimulation (LFS; 900 stimuli delivered at 2 Hz) of the Schaffer collateral-commissural pathway in naïve slices did not induce long-term depression (LTD) of synaptic transmission. However, if long-term potentiation (LTP) was firstly induced in the pathway then LFS generated an LTD-like effect (i.e. depotentiation of LTP). Depotentiation could be induced 2 h (the longest time… CONTINUE READING

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