An investigation into the potential for activity-dependent regeneration of the rubrospinal tract after spinal cord injury.

@article{Harvey2005AnII,
  title={An investigation into the potential for activity-dependent regeneration of the rubrospinal tract after spinal cord injury.},
  author={Philip J Harvey and Joey K Grochmal and Wolfram Tetzlaff and Tessa Gordon and David J. Bennett},
  journal={The European journal of neuroscience},
  year={2005},
  volume={22 12},
  pages={3025-35}
}
We tested whether regeneration of transected rubrospinal tract (RST) axons is facilitated by a prolonged electrical stimulation of these axons. A peripheral nerve was grafted to the transected RST at the cervical level (C4/5) of adult rats, providing a permissive environment for regeneration of rubrospinal axons. Direct antidromic stimulation of the RST was applied immediately after grafting through a microwire inserted just rostral to the RST lesion, using a 1-h 20-Hz supramaximal stimulation… CONTINUE READING