An investigation into the mechanism of protection by local passive immunization with monoclonal antibodies against Streptococcus mutans.

@article{Ma1990AnII,
  title={An investigation into the mechanism of protection by local passive immunization with monoclonal antibodies against Streptococcus mutans.},
  author={Julian K-C Ma and M K Hunjan and Roger V. Smith and Charles G. Kelly and Thomas Lehner},
  journal={Infection and immunity},
  year={1990},
  volume={58 10},
  pages={3407-14}
}
Local oral passive immunization with Streptococcus mutans-specific monoclonal antibody (MAb) (Guy's 13) prevented recolonization by indigenous S. mutans in human volunteers who had first been treated with a conventional antibacterial agent (chlorhexidine). The F(ab')2 fragment of the MAb was as protective as the intact immunoglobulin G, but the Fab fragment of the molecule failed to prevent recolonization of S. mutans. In subjects receiving the MAb Fab fragment, S. mutans levels in dental… CONTINUE READING

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