An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties

@article{Screen2004AnII,
  title={An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties},
  author={Hazel R. C. Screen and D. A. Lee and Dan L. Bader and Julia C Shelton},
  journal={Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine},
  year={2004},
  volume={218},
  pages={109 - 119}
}
  • H. ScreenD. Lee J. Shelton
  • Published 1 February 2004
  • Engineering, Biology
  • Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Abstract During physiological loading, a tendon is subjected to tensile strains in the region of up to 6 per cent. These strains are reportedly transmitted to cells, potentially initiating specific mechano-transduction pathways. The present study examines the local strain fields within tendon fascicles subjected to tensile strain in order to determine the mechanisms responsible for fascicle extension. A hierarchical approach to the analysis was adopted, involving micro and macro examination… 

Figures from this paper

The micro-structural strain response of tendon

An inhomogeneous strain response throughout the matrix and large variability between samples were demonstrated, which suggested a rotary component to tendon response, which may indicate a helical organisation to the tendon matrix.

Local Strain Measurement within Tendon

This study demonstrates a technique for analysing local strains within viable tendon explants, during both loading and unloading of the tissue, and indicates that sliding behaviour is reversible up to strains of 5%, and provides the major extension mechanism within the rat‐tail tendon.

Measuring strain distributions in the tendon using confocal microscopy and finite elements

A novel method of analysing the resulting images is presented, to provide an overview of the strain environment throughout the tendon sample, which highlighted widely variable strains within the matrix during stress relaxation, with strains far greater than those applied to the sample.

Multiscale strain analysis of tendon subjected to shear and compression demonstrates strain attenuation, fiber sliding, and reorganization

  • Fei FangS. Lake
  • Engineering, Biology
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 2015
Insight is provided into microscale mechanisms responsible for multiscale strain attenuation of tendons under non‐tensile macroscale loading and nuclear aspect ratios exhibited smaller changes for distal samples, suggesting that cells are more shielded from deformation in the distal region.

The mechanics of flexor tendon adhesions

Compared microstrains and macrostrains in adhesions of immobilized and mobilized partially lacerated flexor digitorum profundus tendons in a New Zealand White rabbit model, it has been possible to visualize, define, and quantify local adhesion tissue mechanics for the first time.

Investigating load relaxation mechanics in tendon.

  • H. Screen
  • Engineering, Biology
    Journal of the mechanical behavior of biomedical materials
  • 2008

The Micromechanical Environment of the Impinged Achilles Tendon Insertion

Mechanical deformation applied to tendon at the tissue-scale is transferred to the microscale — including the extracellular matrix (ECM), the pericellular matrix (PCM), the cell and the nucleus —

Fascicle-scale loading and failure behavior of the Achilles tendon.

The consistently higher moduli values of the single (strongest) fascicle indicate that the overall response of the tendon may be dominated by a subset of "strongest" fascicles, useful for developing computational models representing single fascicle and/or fascicle group mechanical behavior.

Tendon tissue microdamage and the limits of intrinsic repair.

...

References

SHOWING 1-10 OF 49 REFERENCES

Development of a technique to determine strains in tendons using the cell nuclei.

This study has developed a means to quantify the local strain fields within a fascicle by monitoring the relative movement and deformation of fluorescently labelled tenocyte nuclei.

Recruitment of tendon crimp with applied tensile strain.

This work used optical coherence tomography to determine how crimp period changed as a function of applied tensile strain in rat tail tendon fascicles, and showed a visual correspondence between features indicative of crimp pattern.

Mechanical behaviour of tendon in vitro. A preliminary report.

  • M. Abrahams
  • Biology, Materials Science
    Medical & biological engineering
  • 1967
It was found that the tendon stress-strain curve for successive cycles was reporducible provided that strain on the specimen did not exceed 2·0–4·0%.

Mechanical behaviour of tendonIn vitro

  • M. Abrahams
  • Materials Science
    Medical and biological engineering
  • 2006
The mechanical behaviour of horse and human tendon, as characterised by the stress-strain curve, has been examined with respect to load-strain cycling and strain rate. It was found that the tendon

The multicomposite structure of tendon.

A revised morphological model for the crimp structure of tendon is presented and small bunches of collagen fibrils removed from the tendon are shown to exhibit the simple planar zig-zag morphology described in previous literature.

The Proliferative Response of Isolated Human Tendon Fibroblasts to Cyclic Biaxial Mechanical Strain *

It is shown that application of mechanical stress to tendon fibroblasts resulted in an alteration of cellular proliferation depending on the stress time, which may implicate future modifications in the treatment of ligament and tendon injuries.

In situ cell nucleus deformation in tendons under tensile load; a morphological analysis using confocal laser microscopy

An in vivo model for load‐modulated remodeling in the rabbit flexor tendon

Using this unique in vivo model, this research clearly elucidates how changing tissue function (by removing compressive forces) rapidly alters tissue form.