An investigation into keratinolytic enzymes to enhance ungual drug delivery.

@article{Mohori2007AnII,
  title={An investigation into keratinolytic enzymes to enhance ungual drug delivery.},
  author={Martina Mohor{\vc}i{\vc} and Ana Torkar and Jo{\vz}ica Friedrich and Julijana Kristl and Sudaxshina Murdan},
  journal={International journal of pharmaceutics},
  year={2007},
  volume={332 1-2},
  pages={196-201}
}
The topical therapy of nail diseases is limited by the low permeability of drugs through the nail plate. To increase drug penetration, the integrity of the nail plate must be compromised to a certain extent. We hypothesised that keratinolytic enzymes might decrease the barrier properties of the nail plate by hydrolysing the nail keratins, and thereby enhance ungual drug permeation. To determine enzyme action on nail plates, nail clippings were incubated at 35 degrees C, in the presence of… CONTINUE READING