An invertible element of DNA controls phase variation of type 1 fimbriae of Escherichia coli.

@article{Abraham1985AnIE,
  title={An invertible element of DNA controls phase variation of type 1 fimbriae of Escherichia coli.},
  author={Jesse M. Abraham and Cynthia S. Freitag and Jan Clements and Barry I. Eisenstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 17},
  pages={5724-7}
}
The expression of type 1 fimbriae (pili) of Escherichia coli is turned on and off at the transcriptional level at a high frequency (10(-3) per cell per generation) in a process termed phase variation. Using Southern blot and DNA sequence analysis, we have detected a genomic rearrangement in the switch region immediately upstream of the fimbrial structural gene. This rearrangement involves an invertible 314-base-pair segment of DNA whose alternating orientation apparently results in the on-and… CONTINUE READING