An inverted TATA box directs downstream transcription of the bone sialoprotein gene

@inproceedings{JackJ2005AnIT,
  title={An inverted TATA box directs downstream transcription of the bone sialoprotein gene},
  author={LI JackJ. and Richard H. KIMt},
  year={2005}
}
  • LI JackJ., Richard H. KIMt
  • Published 2005
The orientation oftheTATA box is thought to direct downstream transcription of eukaryotic genes by RNA polymerase II. However, the putative TATA box in the promoter of the bone sialoprotein (BSP) gene, which codes for a tissue-specific and developmentally regulated bone matrix protein, is inverted (5'TTTATA-3') relative to the consensus TATA box sequence (5'-TATAAA-3') and is overlapped by a vitamin D3-response element. Here we show that the inverted TATA sequence in the rat BSP gene binds to… CONTINUE READING