An inverse electron demand Diels-Alder-based total synthesis of defucogilvocarcin V and some C-8 analogues.

@article{Nandaluru2012AnIE,
  title={An inverse electron demand Diels-Alder-based total synthesis of defucogilvocarcin V and some C-8 analogues.},
  author={Penchal Reddy Nandaluru and G. Bodwell},
  journal={The Journal of organic chemistry},
  year={2012},
  volume={77 18},
  pages={
          8028-37
        }
}
A concise total synthesis of defucogilvocarcin V is reported. The key features of the approach are the formation of the C-ring using a vinylogous Knoevenagel/transesterification reaction and construction of the D-ring by way of an inverse electron demand Diels-Alder-driven domino reaction. The resulting C-8 ester functionality provides a handle for the synthesis of defucogilvocarcin V as well as some C-8 analogues from a common late-stage intermediate. 
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