An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males.

@article{Do2010AnIP,
  title={An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males.},
  author={Thuy Quynh N Do and Esma Ucisik-Akkaya and Charronne F. Davis and Brittany A. Morrison and Mehmet Tevfik Dorak},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1802 2},
  pages={
          292-300
        }
}
The interferon regulatory factor (IRF) family of DNA-binding proteins regulates expression of interferon-inducible genes with roles in the immune response and carcinogenesis. IRF4 is involved in the differentiation of B and T cells and is overexpressed in B-cell malignancies as a result of c-REL (NF-kappaB) hyperactivation. IRF4 polymorphisms are associated with susceptibility to chronic lymphoid leukemia (CLL) and non-Hodgkin lymphoma (NHL). We examined 13 IRF4 SNPs in 114 cases of childhood… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 31 CITATIONS

Sex Differences in Cancer: Epidemiology, Genetics and Therapy

  • Biomolecules & therapeutics
  • 2018
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

IRF4 rs12203592 functional variant and melanoma survival.

  • International journal of cancer
  • 2017
VIEW 1 EXCERPT
CITES RESULTS

Sexual Dimorphism in Innate Immunity

  • Clinical Reviews in Allergy & Immunology
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND