An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN.

@article{Dupont2003AnIP,
  title={An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN.},
  author={Annabelle Dupont and Pierre Fontana and Christilla Bachelot-Loza and Jean-Luc Reny and Ivan Bi{\'e}che and Florence Desvard and Martine Aiach and Pascale Gaussem},
  journal={Blood},
  year={2003},
  volume={101 5},
  pages={1833-40}
}
Protease-activated receptor 1 (PAR-1), the main thrombin receptor on vascular cells, plays a key role in platelet activation. We examined the range of PAR-1 expression on platelets, obtained twice, 1 week apart, from 100 healthy subjects and found a 2-fold interindividual variation in receptor numbers (95% CI = 858-1700). Because PAR-1 density was stable with time (r(2) = 76%, P <.001), we sought a genetic explanation for the observed variability. To validate this approach, we also analyzed the… CONTINUE READING