An introduction to the free radical hypothesis in Parkinson's disease.

@article{Olanow1992AnIT,
  title={An introduction to the free radical hypothesis in Parkinson's disease.},
  author={Charles W. Olanow},
  journal={Annals of neurology},
  year={1992},
  volume={32 Suppl},
  pages={S2-9}
}
Iron-induced oxidant stress has been implicated in the pathogenesis of Parkinson's disease. An increasing body of evidence now indicates that in Parkinson's disease the environment within the substantia nigra is conducive to the formation of cytotoxic free radicals and cell degeneration. Dopamine neurons may be particularly vulnerable because of the oxidative metabolism of dopamine and the potential of neuromelanin to promote the site-specific accumulation and reduction of iron. This hypothesis… CONTINUE READING

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