An introduction to TRP channels.

@article{Ramsey2006AnIT,
  title={An introduction to TRP channels.},
  author={Ian Scott Ramsey and Markus Delling and David E. Clapham},
  journal={Annual review of physiology},
  year={2006},
  volume={68},
  pages={
          619-47
        }
}
The aim of this review is to provide a basic framework for understanding the function of mammalian transient receptor potential (TRP) channels, particularly as they have been elucidated in heterologous expression systems. Mammalian TRP channel proteins form six-transmembrane (6-TM) cation-permeable channels that may be grouped into six subfamilies on the basis of amino acid sequence homology (TRPC, TRPV, TRPM, TRPA, TRPP, and TRPML). Selected functional properties of TRP channels from each… 

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References

SHOWING 1-10 OF 310 REFERENCES

The TRP Superfamily of Cation Channels

Members of the TRP superfamily function in various processes, although their roles are best established in sensory modalities ranging from vision to hearing, taste, pheromone detection, pain perception, and osmosensation, which have relevance for human health.

Identification and characterization of the murine TRPM4 channel.

Function and pharmacology of TRPM cation channels

  • C. Harteneck
  • Biology, Chemistry
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2005
The known functions, activation mechanisms, and pharmacological modulations of the TRPM channels are summarized.

Diversity of TRP channel activation.

It will be shown that lipid messengers related to arachidonic acid are endogenous TRPV4 activators and a voltage-dependent gating mechanism will be discussed, which includes an open pore block by Mg2+ and a highly Ca2+-sensitive mechanism of inactivation.

Proteins modulating TRP channel function.

The TRPM ion channel subfamily: molecular, biophysical and functional features.

Formation of Novel TRPC Channels by Complex Subunit Interactions in Embryonic Brain*

This complex assembly mechanism increases the diversity of TRPC channels in mammalian brain and may generate novel heteromers that have specific roles in the developing brain.

Alternative Splicing Switches the Divalent Cation Selectivity of TRPM3 Channels*

These results show that alternative splicing can be a mechanism to produce channels with very different selectivity profiles, and unambiguously show that TRPM3 proteins constitute a pore-forming channel subunit and localize the position of the ion-conducting pore within theTRPM3 protein.

Gating of TRP channels: a voltage connection?

A thermodynamic principle is elaborated, which predicts that the small gating charge of TRP channels is a crucial factor for the large voltage shifts induced by various stimuli, and indicates that, although the voltage sensor is not yet known, the C‐terminus may substantially change the voltage dependence of these channels.
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