An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice

@inproceedings{Sadacca2010AnIC,
  title={An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice},
  author={L. Amanda Sadacca and Katja A Lamia and Andrew S Delemos and Barak Blum and Charles J. Weitz},
  booktitle={Diabetologia},
  year={2010}
}
Loss of circadian clocks from all tissues causes defective glucose homeostasis as well as loss of feeding and activity rhythms. Little is known about peripheral tissue clocks, so we tested the hypothesis that an intrinsic circadian clock of the pancreas is important for glucose homeostasis. We monitored real-time bioluminescence of pancreas explants from circadian reporter mice and examined clock gene expression in beta cells by immunohistochemistry and in situ hybridisation. We generated mice… CONTINUE READING