An intrinsic checkpoint model for regulation of replication origins.

Abstract

A recent paper by Alvino et al., (MCB 2007; 27:6396) challenges the standard model of the DNA replication checkpoint. Their work shows that the checkpoint does not simply prevent late origins from firing in the presence of the nucleotide synthesis inhibitor hydroxyurea; instead it delays origin firing to maintain the regular order of origin firing relative… (More)

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Cite this paper

@article{Rhind2008AnIC, title={An intrinsic checkpoint model for regulation of replication origins.}, author={Nicholas Rhind}, journal={Cell cycle}, year={2008}, volume={7 17}, pages={2619-20} }