An intrinsic cell cycle checkpoint pathway mediated by MEK and ERK in Drosophila.

@article{Mogila2006AnIC,
  title={An intrinsic cell cycle checkpoint pathway mediated by MEK and ERK in Drosophila.},
  author={Vladic Mogila and Fan Xia and Willis X. Li},
  journal={Developmental cell},
  year={2006},
  volume={11 4},
  pages={575-82}
}
Cell cycle checkpoints are surveillance mechanisms that safeguard genome integrity. While the extrinsic pathways that halt the cell cycle in response to DNA damages have been well documented, the intrinsic pathways that ensure orderly progression of cell cycle events are not well understood. We demonstrate that Drosophila MEK and ERK constitute an essential intrinsic checkpoint pathway that restrains cell cycle progression in the absence of DNA damage and also responds to ionizing radiation to… CONTINUE READING

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