An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells.

Abstract

GATA-1 is a tissue-specific transcription factor that is essential for the production of red blood cells. Here we show that overexpression of GATA-1 in erythroid cells inhibits their differentiation, leading to a lethal anaemia. Using chromosome-X-inactivation of a GATA-1 transgene and chimaeric animals, we show that this defect is intrinsic to erythroid… (More)

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Cite this paper

@article{Whyatt2000AnIB, title={An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells.}, author={Daniel Whyatt and Fokke Lindeboom and Alar Karis and R. Ferreira and Eric Milot and Rudi W Hendriks and Marienke de Bruijn and Antonius P M Langeveld and J Gribnau and Frank G. Grosveld and Sjaak Philipsen}, journal={Nature}, year={2000}, volume={406 6795}, pages={519-24} }