An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain

Abstract

The glucagon-like peptide-1 receptor is a class B G protein coupled receptor (GPCR) that plays key roles in glucose metabolism and is a major therapeutic target for diabetes. The classic two-domain model for class B GPCR activation proposes that the apo-state receptor is auto-inhibited by its extracellular domain, which physically interacts with the… (More)
DOI: 10.1038/celldisc.2016.42

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Cite this paper

@inproceedings{Yin2016AnIA, title={An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain}, author={Yanting Yin and X. Edward Zhou and Li Hou and Li-hua Zhao and Bo Liu and Gaihong Wang and Y. H. Jiang and Karsten Melcher and H. Eric Xu}, booktitle={Cell Discovery}, year={2016} }