An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models: relationship between fibrosis and angiogenesis.

@article{Vanheule2008AnIM,
  title={An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models: relationship between fibrosis and angiogenesis.},
  author={Eline Vanheule and Anja M Geerts and Jacques Van Huysse and Daphn{\'e} Schelfhout and Marleen Praet and Hans R Van Vlierberghe and Martine M De Vos and Isabelle O Colle},
  journal={International journal of experimental pathology},
  year={2008},
  volume={89 6},
  pages={419-32}
}
This intravital fluorescence microscopy (IVFM) study validates cirrhotic mice models and describes the different intrahepatic alterations and the role of angiogenesis in the liver during genesis of cirrhosis. Cirrhosis was induced by subcutaneous injection of carbon tetrachloride (CCl(4)) and by common bile duct ligation (CBDL) in mice. Diameters of sinusoids, portal venules (PV), central venules (CV) and shunts were measured at different time points by IVFM. Thereafter, liver samples were… CONTINUE READING
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