An intraperitoneally administered pentapeptide protects against Abeta (1-42) induced neuronal excitation in vivo.

@article{Juhsz2009AnIA,
  title={An intraperitoneally administered pentapeptide protects against Abeta (1-42) induced neuronal excitation in vivo.},
  author={G{\'a}bor Juh{\'a}sz and {\'A}rp{\'a}d M{\'a}rki and Gabriella Vass and Livia F{\"u}l{\"o}p and D{\'e}nes Budai and Botond Penke and Gy{\"o}rgy Falkay and Viktor Szegedi},
  journal={Journal of Alzheimer's disease : JAD},
  year={2009},
  volume={16 1},
  pages={189-96}
}
The underlying cause of Alzheimer's disease (AD) is thought to be the accumulation and aggregation of a misfolded protein, amyloid-beta (Abeta). A promising strategy against AD is the application of protective, peptide-based neuroprotective agents that selectively bind to Abeta. We recently described a pentapeptide, LPYFDa, which recognizes Abeta (1-42) and protects neurons against the toxic effects of aggregated Abeta (1-42) both in vitro and in vivo. Our previous work indicated that the in… CONTINUE READING

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