An intramolecular recombination mechanism for the formation of the rRNA gene palindrome of Tetrahymena thermophila.

@article{Butler1995AnIR,
  title={An intramolecular recombination mechanism for the formation of the rRNA gene palindrome of Tetrahymena thermophila.},
  author={David K. Butler and Lauren E Yasuda and M C Yao},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 12},
  pages={7117-26}
}
Large palindromic DNAs are found in a wide variety of eukaryotic cells. In Tetrahymena thermophila, a large palindrome is formed from a single rRNA gene (rDNA) during nuclear differentiation. We present evidence that a key step in the formation of the rDNA palindrome of T. thermophila involves homologous intramolecular recombination. Heteroduplex micronuclear rDNA molecules were constructed in vitro and microinjected into developing macronuclei, where they formed palindromes. Analysis of the… CONTINUE READING

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