An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels

Abstract

Phosphorylated phosphoinositide lipids (PPIs) are low-abundance signaling molecules that control signal transduction pathways and are necessary for cellular homeostasis. The PPI phosphatidylinositol (3,5)-bisphosphate (PI(3,5)P2) is essential in multiple organ systems. PI(3,5)P2 is generated from PI3P by the conserved lipid kinase Fab1/PIKfyve. Defects in… (More)
DOI: 10.1091/mbc.E16-06-0390

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Cite this paper

@inproceedings{Lang2017AnII, title={An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels}, author={Michael J Lang and Bethany S. Strunk and Nadia Azad and Jason L. Petersen and Lois S Weisman}, booktitle={Molecular biology of the cell}, year={2017} }