An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease

@article{Yan1997AnIP,
  title={An intracellular protein that binds amyloid-$\beta$ peptide and mediates neurotoxicity in Alzheimer's disease},
  author={Shi Du Yan and Jin Fu and Claudio Soto and Xi Chen and Huaijie Zhu and Futwan Al-Mohanna and Kate S Collison and Aiping Zhu and Eric Stern and Takaomi C. Saido and Masaya Tohyama and Satoshi Ogawa and Alex E. Roher and David M. Stern},
  journal={Nature},
  year={1997},
  volume={389},
  pages={689-695}
}
Amyloid-β is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in neurons affected in Alzheimer's disease. ERAB immunoprecipitates with amyloid-β, and when cell cultures are exposed to amyloid-β, ERAB inside the cell is rapidly redistributed to the plasma membrane. The toxic effect of amyloid-β on… 

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