An intracellular phosphate buffer filters transient fluctuations in extracellular phosphate levels.

@article{Thomas2005AnIP,
  title={An intracellular phosphate buffer filters transient fluctuations in extracellular phosphate levels.},
  author={Melissa R. Thomas and Erin K O'Shea},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 27},
  pages={9565-70}
}
To survive in a dynamic and unpredictable environment, cells must correctly interpret and integrate extracellular signals with internal factors. In particular, internal stores of nutrients must be managed for use during periods of nutrient limitation. To gain insight into this complex process, we combined biochemical and spectroscopic techniques to follow the dynamics of the phosphate responsive signaling pathway in both single yeast cells and populations. We demonstrate that the phosphate… CONTINUE READING

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