An intracellular motif of P2X(3) receptors is required for functional cross-talk with GABA(A) receptors in nociceptive DRG neurons.

@article{Toulm2007AnIM,
  title={An intracellular motif of P2X(3) receptors is required for functional cross-talk with GABA(A) receptors in nociceptive DRG neurons.},
  author={Estelle Toulm{\'e} and Dominique Blais and Claire L{\'e}ger and Marc Landry and Maurice Garret and Philippe S{\'e}gu{\'e}la and Eric Bou{\'e}-Grabot},
  journal={Journal of neurochemistry},
  year={2007},
  volume={102 4},
  pages={1357-68}
}
Functional cross-talk between structurally unrelated P2X ATP receptors and members of the 'cys-loop' receptor-channel superfamily represents a recently-discovered mechanism for rapid modulation of information processing. The extent and the mechanism of the inhibitory cross-talks between these two classes of ionotropic receptors remain poorly understood, however. Both ionic and molecular coupling were proposed to explain cross-inhibition between P2X subtypes and GABA(A) receptors, suggesting a… CONTINUE READING