An intracellular form of cathepsin B contributes to invasiveness in cancer.

  title={An intracellular form of cathepsin B contributes to invasiveness in cancer.},
  author={Anna M Szpaderska and Allen Frankfater},
  journal={Cancer research},
  volume={61 8},
Cathepsin B is a lysosomal cysteine proteinase whose expression and trafficking are frequently altered in cancer, and plasma membrane and secreted forms are thought to contribute to the invasive and metastatic properties of malignant tumors. We have manipulated the expression of cathepsin B in several tumor cell lines and measured their capacity to invade through a reconstituted extracellular (Matrigel) matrix. Transient expression of human cathepsin B in a poorly metastatic B16F1 murine… CONTINUE READING


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