An interstitial deletion of 6p24-p25 proximal to the FKHL7 locus and including AP-2alpha that affects anterior eye chamber development.

@article{Davies1999AnID,
  title={An interstitial deletion of 6p24-p25 proximal to the FKHL7 locus and including AP-2alpha that affects anterior eye chamber development.},
  author={Angela F. Davies and G. Ertuðrul Mirza and FrancesA. Flinter and Jiannis Ragoussis},
  journal={Journal of medical genetics},
  year={1999},
  volume={36 9},
  pages={
          708-10
        }
}
The FKHL7 gene has been implicated in the pathogenesis of glaucoma/autosomal dominant iridogoniodysgenesis (IGDA) (IRID1). This has been supported by mutations in some glaucoma and IGDA patients and the development of anterior eye chamber anomalies in patients with 6p deletions affecting the 6p25 region. We report a case with anterior eye chamber anomalies and an interstitial deletion of 6p24-p25 that does not include the FKHL7 gene, suggesting the possible additional involvement of another… CONTINUE READING
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