An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment.

@article{Lynch2012AnIA,
  title={An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment.},
  author={Magnus David Lynch and Andrew J. H. Smith and Marco de Gobbi and Maria Flenley and Jim R. Hughes and Douglas Vernimmen and Helena Ayyub and Jacqueline A. Sharpe and Jacqueline A. Sloane-Stanley and Linda Sutherland and Stephen Earl Meek and Tom Burdon and Richard J. Gibbons and David Garrick and Douglas R Higgs},
  journal={The EMBO journal},
  year={2012},
  volume={31 2},
  pages={317-29}
}
The role of DNA sequence in determining chromatin state is incompletely understood. We have previously demonstrated that large chromosomal segments from human cells recapitulate their native chromatin state in mouse cells, but the relative contribution of local sequences versus their genomic context remains unknown. In this study, we compare orthologous chromosomal regions for which the human locus establishes prominent sites of Polycomb complex recruitment in pluripotent stem cells, whereas… CONTINUE READING
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