An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome

@article{Harrison2014AnIS,
  title={An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome},
  author={Christine J Harrison and Anthony V Moorman and Claire J. Schwab and Andrew J. Carroll and Elizabeth A. Raetz and Meenakshi Devidas and Sabine Strehl and Karin Nebral and Jochen Harbott and Andrea Teigler-Schlegel and Martin Zimmerman and N Dastuge and Andr{\'e} Baruchel and J Steve Soulier and M-F Auclerc and Andishe Attarbaschi and Georg Mann and Batia Stark and Giovanni Cazzaniga and Lucy Chilton and Peter Vandenberghe and Erik Forestier and Ir{\'e}n Haltrich and Susana C. Raimondi and Mayur Parihar and J. B. Bourquin and Jo{\"e}lle Tchinda and Claudia Haferlach and Ajay J. Vora and Stephen P Hunger and N A Heerema and Oskar Arthur Haas},
  journal={Leukemia},
  year={2014},
  volume={28},
  pages={1015-1021}
}
Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of childhood B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). To date, fluorescence in situ hybridisation (FISH), with probes specific for the RUNX1 gene, provides the only reliable detection method (five or more RUNX1 signals per cell). Patients with iAMP21 are older (median age 9 years) with a low white cell count. Previously, we demonstrated a high relapse risk when these patients were… CONTINUE READING