An international evaluation of the murine local lymph node assay and comparison of modified procedures.

@article{Kimber1995AnIE,
  title={An international evaluation of the murine local lymph node assay and comparison of modified procedures.},
  author={I A N Kimber and Jennifer Hilton and Rebecca Jane Dearman and G. Frank Gerberick and Cindy A. Ryan and David A Basketter and E W Scholes and Gregory S. Ladics and Scott E Loveless and Robert V. House},
  journal={Toxicology},
  year={1995},
  volume={103 1},
  pages={63-73}
}
The murine local lymph node assay is a predictive test for the identification of skin-sensitizing chemicals. The method has been the subject both of national inter-laboratory studies and of extensive comparisons with guinea pig tests. In the investigations reported here, the local lymph node assay has been evaluated further in the context of an international study comprising five independent laboratories. In addition, the influence of minor modifications to the standard assay procedure on the… CONTINUE READING
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