An international consensus approach to the management of atypical hemolytic uremic syndrome in children

@article{Loirat2015AnIC,
  title={An international consensus approach to the management of atypical hemolytic uremic syndrome in children},
  author={Chantal Loirat and Fadi Fakhouri and Gema Ariceta and Nesrin Beşbaş and Martin Bitzan and Anna Bjerre and Rosanna Coppo and Francesco Emma and Sally M. Johnson and Diana Karpman and Daniel Landau and Craig B. Langman and Anne-Laure Lapeyraque and Christoph Licht and Carla Nester and Carmine Pecoraro and Magdalena Riedl and Nicole C. A. J. van de Kar and Johan van de Walle and Marina S. Vivarelli and V{\'e}ronique Fr{\'e}meaux-Bacchi},
  journal={Pediatric Nephrology},
  year={2015},
  volume={31},
  pages={15-39}
}
Atypical hemolytic uremic syndrome (aHUS) emerged during the last decade as a disease largely of complement dysregulation. This advance facilitated the development of novel, rational treatment options targeting terminal complement activation, e.g., using an anti-C5 antibody (eculizumab). We review treatment and patient management issues related to this… CONTINUE READING