An internally positioned signal can direct attachment of a glycophospholipid membrane anchor

@article{Caras1991AnIP,
  title={An internally positioned signal can direct attachment of a glycophospholipid membrane anchor},
  author={Ingrid W. Caras},
  journal={The Journal of Cell Biology},
  year={1991},
  volume={113},
  pages={77 - 85}
}
All known glycophosphatidylinositol (GPI)-anchored membrane proteins contain a COOH-terminal hydrophobic domain necessary for signalling anchor attachment. To examine the requirement that this signal be at the COOH terminus of the protein, we constructed a chimeric protein, DAFhGH, in which human growth hormone (hGH) was fused to the COOH terminus of decay accelerating factor (DAF) (a GPI-anchored protein), thereby placing the GPI signal in the middle of the chimeric protein. We show that the… CONTINUE READING

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