An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface

@article{Sauter1996AnIS,
  title={An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface},
  author={Markus Sauter and Annegret Pelchen-Matthews and Rita Bron and Mark Marsh and Celia C LaBranche and Patricia J. Vance and Josephine Romano and Beth S Haggarty and Timothy K. Hart and Will W M Lee and James A Hoxie},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={132},
  pages={795 - 811}
}
A Tyr to Cys mutation at amino acid position 723 in the cytoplasmic domain of the simian immunodeficiency virus (SIV) transmembrane (TM) molecule has been shown to increase expression of envelope glycoproteins on the surface of infected cells. Here we show that Tyr-723 contributes to a sorting signal that directs the rapid endocytosis of viral glycoproteins from the plasma membrane via coated pits. On cells infected by SIVs with a Tyr at position 723, envelope glycoproteins were transiently… CONTINUE READING

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