An internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin domain protein.

Abstract

Precursor proteolysis is a crucial mechanism for regulating protein structure and function. Signal peptidase (SP) is an enzyme with a well defined role in cleaving N-terminal signal sequences but no demonstrated function in the proteolysis of cellular precursor proteins. We provide evidence that SP mediates intraprotein cleavage of IgSF1, a large cellular… (More)
DOI: 10.1074/jbc.M807527200

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Cite this paper

@article{Robakis2008AnIS, title={An internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin domain protein.}, author={Thalia Robakis and Beata Bąk and Shu-huei Lin and Daniel J Bernard and Peter Scheiffele}, journal={The Journal of biological chemistry}, year={2008}, volume={283 52}, pages={36369-76} }