An interferon-sensitive response element is involved in constitutive caspase-8 gene expression in neuroblastoma cells.

@article{Ambrosis2007AnIR,
  title={An interferon-sensitive response element is involved in constitutive caspase-8 gene expression in neuroblastoma cells.},
  author={Alessandro De Ambrosis and Ida Casciano and Michela Croce and Gabriella Pagnan and Luana Radi{\'c} and Barbara Banelli and Angela di Vinci and Giorgio Allemanni and Gian Paolo Tonini and Mirco Ponzoni and Massimo Romani and Silvano Ferrini},
  journal={International journal of cancer},
  year={2007},
  volume={120 1},
  pages={39-47}
}
We previously identified a 1.2 Kb DNA element (P-1161/+16), 5' to caspase-8 exon-1, that acts as promoter in caspase-8-positive, but not in caspase-8-negative neuroblastoma (NB) cells. The P-1161/+16 DNA element regulates both constitutive and interferon IFN-gamma-inducible caspase-8 expression. Two GAS (IFN-activated sequence, STAT-1 binding site) and two… CONTINUE READING